Marijuana compound may stop deadly cancer metastasis
We've known about medical applications of cannabis (or marijuana) for years, but the research findings of two scientists studying it have the potential to change the deadliness of cancer forever. A cannabis compound known as cannabidiol can stop metastasis in many types of aggressive cancers, found the researchers from California Pacific Medical Center in San Francisco.
Cannabidiol (CBD) is a non-toxic, non-psychoactive chemical found in the cannabis plant, that had already been effective in relieving convulsion, inflammation, anxiety and nausea, and in treating schizophrenia and dystonia. For the 2007 study, Sean McAllister, who was specifically studying the effects of cannabidiol, collaborated with Pierre Desprez, who for the last 10 years has been studying the ID-1 gene in cancer that causes metastasis.
Metastasis is when a cancer spreads from the primary tumor area to other parts of the body, typically using the bloodstream or lymphatic system, and is one of the hallmarks of a tumor becoming malignant.
"What we found was that his Cannabidiol could essentially 'turn off' the ID-1," Desprez told The Huffington Post. "We likely would not have found this on our own," he added.
"That's why collaboration is so essential to scientific discovery."
Since publishing their study, the two went on to study the effect of CBD on other cancers.
"Now we've found that Cannabidiol works with many kinds of aggressive cancers brain, prostate any kind in which these high levels of ID-1 are present." said Desprez.
Since CBD has already been safely used by people for other ailments, the two hope that clinical trials can begin soon. However, treating cancer metastasis in this way requires more than just lighting up.
"We used injections in the animal testing and are also testing pills," he said. "But you could never get enough cannabidiol for it to be effective just from smoking."
The two are now working on synthesizing the cannabidiol in the lab, rather than using samples from the plant, which should not only make it more potent, but also hopefully clear any obstacles at getting the drug approved.
By Scott Sutherland | Geekquinox Thu, 20 Sep, 2012..
Cancer Hope By Paul Armentano
Cannabinoids As Cancer Hope
by Paul Armentano
Senior Policy Analyst
NORML | NORML Foundation
Cannabinoids possess anticancer activity [and may] possibly represent a new class of anti-cancer drugs that retard cancer growth, inhibit angiogenesis (the formation of new blood vessels) and the metastatic spreading of cancer cells." So concludes a comprehensive review published in the October 2005 issue of the scientific journal Mini-Reviews in Medicinal Chemistry.
Not familiar with the emerging body of research touting cannabis' ability to stave the spread of certain types of cancers? You're not alone.
For over 30 years, US politicians and bureaucrats have systematically turned a blind eye to scientific research indicating that marijuana may play a role in cancer prevention -- a finding that was first documented in 1974. That year, a research team at the Medical College of Virginia (acting at the behest of the federal government) discovered that cannabis inhibited malignant tumor cell growth in culture and in mice. According to the study's results, reported nationally in an Aug. 18, 1974, Washington Post newspaper feature, administration of marijuana's primary cannabinoid THC, "slowed the growth of lung cancers, breast cancers and a virus-induced leukemia in laboratory mice, and prolonged their lives by as much as 36 percent."
Despite these favorable preclinical findings, US government officials dismissed the study (which was eventually published in the Journal of the National Cancer Institute in 1975), and refused to fund any follow-up research until conducting a similar - though secret - clinical trial in the mid-1990s. That study, conducted by the US National Toxicology Program to the tune of $2 million concluded that mice and rats administered high doses of THC over long periods experienced greater protection against malignant tumors than untreated controls.
Rather than publicize their findings, government researchers once again shelved the results, which only came to light after a draft copy of its findings were leaked in 1997 to a medical journal, which in turn forwarded the story to the national media.
Nevertheless, in the decade since the completion of the National Toxicology trial, the U.S. government has yet to encourage or fund additional, follow up studies examining the cannabinoids' potential to protect against the spread cancerous tumors.
Fortunately, scientists overseas have generously picked up where US researchers so abruptly left off. In 1998, a research team at Madrid's Complutense University discovered that THC can selectively induce apoptosis (program cell death) in brain tumor cells without negatively impacting the surrounding healthy cells. Then in 2000, they reported in the journal Nature Medicine that injections of synthetic THC eradicated malignant gliomas (brain tumors) in one-third of treated rats, and prolonged life in another third by six weeks.
In 2003, researchers at the University of Milan in Naples, Italy, reported that non-psychoactive compounds in marijuana inhibited the growth of glioma cells in a dose dependent manner and selectively targeted and killed malignant cancer cells.
The following year, researchers reported in the journal of the American Association for Cancer Research that marijuana's constituents inhibited the spread of brain cancer in human tumor biopsies. In a related development, a research team from the University of South Florida further noted that THC can also selectively inhibit the activation and replication of gamma herpes viruses. The viruses, which can lie dormant for years within white blood cells before becoming active and spreading to other cells, are thought to increase one's chances of developing cancers such as Karposis Sarcoma, Burkitts lymphoma, and Hodgkins disease.
More recently, investigators published pre-clinical findings demonstrating that cannabinoids may play a role in inhibiting cell growth of colectoral cancer, skin carcinoma, breast cancer, and prostate cancer, among other conditions. When investigators compared the efficacy of natural cannabinoids to that of a synthetic agonist, THC proved far more beneficial selectively decreasing the proliferation of malignant cells and inducing apoptosis more rapidly than its synthetic alternative while simultaneously leaving healthy cells unscathed.
Nevertheless, US politicians have been little swayed by these results, and remain steadfastly opposed to the notion of sponsoring or even acknowledging this growing body clinical research, preferring instead to promote the unfounded notion that cannabis use causes cancer. Until this bias changes, expect the bulk of research investigating the use of cannabinoids as anticancer agents to remain overseas and, regrettably, overlooked in the public discourse.